Misty's first appearance was in the very first episode of the anime series, Pokémon - I Choose You! In this episode, she first meets Ash after fishing him out of the water when he was trying to get away from a flock of Spearow. Ash then takes Misty's bike from her in order to escape the Spearow, which is then wrecked by Pikachu's Thunder Shock. Misty then tracks down Ash and follows him around on his adventures until he can pay her back, although she eventually forgets about the bike and becomes one of Ash's closest friends in the process.
She is the Cerulean City Gym Leader.
Misty has orange hair tied in a ponytail, wears red suspenders, a yellow tank top,blue denim shorts and red and yellow sneakers.
Her new outfit consists of a yellow sleeveless vest with a blue button,red swimsuit, yellow shorts and orange shoes.
Misty has a slight inferiority complex, mostly due to her three older sisters Daisy (oldest), Violet (second-from-oldest) and Lily (third-from-oldest), who formed the group, "The Three Sensational Sisters" (their synchronized swimming group), and refer to Misty as the "runt"or "weaker one". This complex diminishes over time as Misty grows closer to Daisy. Until Misty resumed her duties as the Cerulean City Gym Leader, her sisters were the ones who directly ran the gym, although when Ash came along to get his Cascade Badge, it was Misty who battled him for it, explicitly referring to herself as being one of the gym leaders during this instance.
Despite being the youngest of four sisters, Misty's the most intelligent and also the most mature and responsible of her sisters, with Violet being the next most intelligent and next most mature and responsible. Even if Misty's sisters can be kind of mean to her, they really do care about her - they just aren't very good at showing it sometimes.
Misty specializes mainly in Water-type Pokémon, which are her favorite type, but she's had other types, and she also deeply admires Lorelei, an Ice-type Pokémon trainer. Misty aims to become a world-class trainer, and her well-trained Pokémon reflect her aspirations of becoming so. Her least favorite type of Pokémon are Bug-type Pokémon, as she has a deep-rooted fear of them (except for the kinds she sees as "cute" or "pretty"). However, Misty's fear lessens over the course of the series - but not to the point where she's totally gotten over it, as shown in A Real Cleffa Hanger.
As the series continues, she gradually shows herself to be kind and sensible. Sometimes she would restrainBrock from girls, often pulling him away by the ear.
In the series, Misty first is seen wearing a yellow tank top with red suspenders and light blue denim shorts. Her shoes were colored red and white, with a yellow streak in the middle. Misty's personality in the anime can be very complex at times. She can be very nice to her friends but will then quickly change moods in a short amount of time, particularly anger. She is quite proficient in anything having to do with water as can be seen in certain episodes where she has ability in fishing, swimming, and overall Water Pokémon training. Even though she wanted to stay with Ash, Misty felt obligated to watch over the Gym. The two went their separate ways, and Misty resumed Gym Leader duties at Cerulean City's Gym.
In this series, Misty wears a pale yellow vest/sleeveless jacket, with a dark blue button and a collar of the same color. She also wears yellow shorts, crimson leotard under her vest, light and burnt orange hi-tops, and white socks. Misty has only appeared as a guest star in the remainder of the Pokémon series. In one of her cameo appearances in the Advanced Generation series, her Togepi evolves into Togetic. Misty releases Togetic after it chooses to stay behind to defend the Mirage Kingdom. After Ash finishes competing in the Hoenn League, he returns home to Pallet Town to find Misty waiting for him. However, she isn't the only one to rejoin Ash, as May, Max, and Brock join him as well for the Battle Frontier challenges. She travels with Ash for two episodes, and shortly after returns to her Gym.